If you're looking for a place to get away, look no further than Irene. Whether you're planning to stay for a night or for the week, the area around Irene has accommodations to fit every need. Search for hotels in Irene with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Irene hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Irene hotel deals are here with our lowest price guarantee.
Hotels in Irene
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Where to stay in Irene?

Holiday Inn Express & Suites Yankton by IHG
Holiday Inn Express & Suites Yankton by IHG
9.2 out of 10, Wonderful, (397)
The price is $123
$141 total
includes taxes & fees
Jul 20 - Jul 21

Best Western Kelly Inn
Best Western Kelly Inn
8.0 out of 10, Very Good, (606)
The price is $106
$117 total
includes taxes & fees
Jul 27 - Jul 28

Econo Lodge Inn & Suites
Econo Lodge Inn & Suites
7.2 out of 10, Good, (665)
The price is $87
$96 total
includes taxes & fees
Jul 23 - Jul 24

Yankton Inn
Yankton Inn
7.2 out of 10, Good, (225)
The price is $85
$94 total
includes taxes & fees
Jul 27 - Jul 28

Comfort Inn Yankton SD
Comfort Inn Yankton SD
8.8 out of 10, Excellent, (610)
The price is $118
$130 total
includes taxes & fees
Aug 3 - Aug 4

Fairfield Inn & Suites by Marriott Yankton
Fairfield Inn & Suites by Marriott Yankton
9.4 out of 10, Exceptional, (133)
The price is $154
$169 total
includes taxes & fees
Jul 20 - Jul 21

Super 8 by Wyndham Beresford
Super 8 by Wyndham Beresford
6.4 out of 10, (260)
The price is $71
$77 total
includes taxes & fees
Jul 27 - Jul 28

Lewis and Clark Resort
Lewis and Clark Resort
8.8 out of 10, Excellent, (227)
The price is $134
$141 total
includes taxes & fees
Jul 20 - Jul 21
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Irene
Pet friendly
Learn more about Irene
You can explore the area's natural beauty at Lincoln Park during your stay.
Check out reviews of Irene hotels guests love

Fairfield Inn & Suites by Marriott Yankton
10/10 Excellent
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Find out more about Irene
Find out more about Irene
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