Hotels in East Prairie

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Where to stay in East Prairie?

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

1. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

$69

$79 total

includes taxes & fees

Oct 18 - Oct 19

A building with a fountain and flower beds in front.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

$66

$74 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A motel with a covered entrance, multiple rooms, and a parking lot.

3. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

$57

$65 total

includes taxes & fees

Oct 22 - Oct 23

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

4. Drury Inn & Suites Sikeston, MO

Sikeston

$94

$108 total

includes taxes & fees

Oct 25 - Oct 26

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

5. Best Western Plus Sikeston I-55

Sikeston

$80

$91 total

includes taxes & fees

Nov 8 - Nov 9

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious lobby with a central atrium, a piano, and a reception desk.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

6. Days Inn and Suites by Wyndham Sikeston

Sikeston

$66

$76 total

includes taxes & fees

Nov 1 - Nov 2

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

7. Hampton Inn Sikeston

Sikeston

$105

$120 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

$101

$115 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a counter, a coffee machine, and seating.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

9. Country Yard Inn and Suite

Sikeston

$58

$70 total

includes taxes & fees

Oct 17 - Oct 18

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

10. Eagle Inn Charleston

Charleston

$66

$74 total

includes taxes & fees

Oct 17 - Oct 18

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

11. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

$95

$108 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

12. TownePlace Suites by Marriott Sikeston

Sikeston

$109

$124 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

A reception area with a counter, a flat-screen TV, and a window with blinds.

13. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

$60

$67 total

includes taxes & fees

Oct 18 - Oct 19

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

14. Comfort Inn & Suites Sikeston I-55

Sikeston

$79

$90 total

includes taxes & fees

Nov 8 - Nov 9

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

15. Super 8 By Wyndham Marston

Marston

$56

$64 total

includes taxes & fees

Oct 21 - Oct 22

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

16. Sleep Inn at Discovery Park of America

Union City

$72

$86 total

includes taxes & fees

Nov 8 - Nov 9

A hotel lobby with a reception desk, seating area, and a large window.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

17. Quality Inn Cairo I-57

Cairo

$69

$77 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with a dark wooden desk, a television, a lamp, a chair, and a mirror on the wall.

A parking lot with a grassy area and trees in the background.

A bathroom with a bathtub, a toilet, and a sink.

A building with multiple floors and a flat roof, surrounded by a grassy area with trees.

18. Reelfoot Lake Inn

Tiptonville

$61

$70 total

includes taxes & fees

Nov 1 - Nov 2

A living room with a sofa, chairs, a glass coffee table, and a TV.

A modern bathroom with a large sink, towel rack, and a mirror reflecting a dining area.

A swimming pool with a clear blue sky and clouds above.

A kitchen area with a coffee machine, microwave, and various appliances.

19. Hospitality House Union City I 69 / US 51

Union City

$54

$64 total

includes taxes & fees

Oct 25 - Oct 26

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

A gym with treadmills, elliptical machines, and stationary bikes.

A hotel room with a large bed, a desk, a chair, and a bedside table.

20. Quality Inn Union City US 51

Union City

$67

$80 total

includes taxes & fees

Nov 8 - Nov 9

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Go beyond your typical stay in East Prairie

Pet friendly

Pool

Family friendly

Top landmarks in East Prairie

Big Oak Tree State Park

8.0/10 (20 reviews)

Big Oak Tree State Park is 10.3 mi (16.6 km) from central East Prairie, why not stop by during your stay.

See properties

Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

See all hotels in East Prairie

A tree-lined landscape with a river and fields.

Check out reviews of East Prairie hotels guests love

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"It was nice having a 2 room suite. Plenty of room. Fridge with freezer was a plus."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Very friendly & professional staff. Trustworthy room attendants, with attention to details. Beds comfortable. Everyone enjoyed the morning breakfast, with a good menu. Cocktail hour widely attended. Would definitely stay here again!"

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent

"Clean all-around. Staff were very pleasant, food was good"

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Sleep Inn at Discovery Park of America

8/10 Good

"Everything was nice. Bed very comfortable."

Reelfoot Lake Inn

8/10 Good

"Dated but descent."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

Hampton Inn Union City

10/10 Excellent

"The room was pretty spacious and very clean with updated furniture. Breakfast was great!"

Frequently asked questions

What hotels do travelers like in East Prairie?

Guests like The Riverstone Hotel Charleston-Sikeston.

Can I book a refundable hotel in East Prairie?

If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in East Prairie be like during my trip?

July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.

Why should I book my East Prairie accommodation with Hotels.com?

There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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