If you're looking for a place to get away, look no further than East Prairie. Whether you're planning to stay for a night or for the week, the area around East Prairie has accommodations to fit every need. Search for hotels in East Prairie with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all East Prairie hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best East Prairie hotel deals are here with our lowest price guarantee.
Hotels in East Prairie
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in East Prairie?

Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
6.8 out of 10, (389)
The price is $65
$72 total
includes taxes & fees
Jul 23 - Jul 24

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.6 out of 10, (572)
The price is $65
$72 total
includes taxes & fees
Jul 17 - Jul 18

Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, (100)
The price is $66
$73 total
includes taxes & fees
Jul 17 - Jul 18

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.2 out of 10, Good, (1001)
The price is $72
$82 total
includes taxes & fees
Jul 20 - Jul 21

Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, (1013)
The price is $88
$100 total
includes taxes & fees
Aug 10 - Aug 11

Country Yard Inn and Suite
Country Yard Inn and Suite
7.2 out of 10, Good, (97)
The price is $65
$77 total
includes taxes & fees
Jul 17 - Jul 18

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
8.4 out of 10, Very Good, (661)
The price is $70
$80 total
includes taxes & fees
Jul 19 - Jul 20

Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
8.4 out of 10, Very Good, (268)
The price is $89
$102 total
includes taxes & fees
Aug 10 - Aug 11

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, (1001)
The price is $80
$92 total
includes taxes & fees
Jul 17 - Jul 18

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, (1000)
The price is $102
$117 total
includes taxes & fees
Jul 27 - Jul 28

Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
6.6 out of 10, (543)
The price is $67
$76 total
includes taxes & fees
Jul 23 - Jul 24

Hampton Inn Sikeston
Hampton Inn Sikeston
8.8 out of 10, Excellent, (361)
The price is $118
$134 total
includes taxes & fees
Jul 27 - Jul 28

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
8.6 out of 10, Excellent, (413)
The price is $108
$122 total
includes taxes & fees
Jul 20 - Jul 21

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott Sikeston
10.0 out of 10, Exceptional, (14)
The price is $122
$138 total
includes taxes & fees
Jul 23 - Jul 24

TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
7.4 out of 10, Good, (3)
The price is $134
$152 total
includes taxes & fees
Jul 27 - Jul 28

Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, (261)
The price is $75
$83 total
includes taxes & fees
Aug 1 - Aug 2

Super 8 By Wyndham Marston
Super 8 By Wyndham Marston
8.0 out of 10, Very Good, (24)
The price is $96
$109 total
includes taxes & fees
Jul 18 - Jul 19

Travel Inn
Travel Inn
5.8 out of 10, (105)
The price is $67
$77 total
includes taxes & fees
Jul 20 - Jul 21

Reelfoot Lake Inn
Reelfoot Lake Inn
7.2 out of 10, Good, (443)
The price is $61
$164 total
includes taxes & fees
Aug 1 - Aug 2

Sleep Inn at Discovery Park of America
Sleep Inn at Discovery Park of America
9.0 out of 10, Wonderful, (247)
The price is $89
$106 total
includes taxes & fees
Jul 27 - Jul 28
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in East Prairie
Pet friendly
Family friendly
Top landmarks in East Prairie
Big Oak Tree State Park
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
Learn more about East Prairie
East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.
Check out reviews of East Prairie hotels guests love
Fairfield by Marriott Inn & Suites Sikeston
10/10 Excellent
Frequently asked questions
Find out more about East Prairie
Find out more about East Prairie
Keep exploring
Keep exploring
- Landmarks
- Hotels close to nearby airports
- Nearby cities
- Top cities in United States of America
- More Hotels
- Most popular destinations
- More ways to book
- Hotels near Ohio River
- Hotels near Discovery Park of America
- Hotels near Reelfoot Lake State Park
- Hotels near Columbus-Belmont State Park
- Hotels near Baptist Memorial Hospital-Union City
- Hotels near Union City Masquerade Theatre
- Hotels near City of Miner Convention Center
- Hotels near Campbell's Point
- Hotels near Marston Community Center
- Hotels near Graham Park
- Hotels near Front Street Studio & Art Gallery
- Hotels near New Madrid Historical Museum
- Hotels near Hunter-Dawson State Historic Site
- Las Vegas Hotels
- New York Hotels
- Orlando Hotels
- Myrtle Beach Hotels
- Chicago Hotels
- San Diego Hotels
- Panama City Beach Hotels
- Destin Hotels
- Ocean City Hotels
- Los Angeles Hotels
- Miami Hotels
- Boston Hotels
- Nashville Hotels
- Gulf Shores Hotels
- Atlantic City Hotels
- Pigeon Forge Hotels
- Atlanta Hotels
- Virginia Beach Hotels
- San Francisco Hotels
- Houston Hotels
Most popular destinations
Hotels
- Cheap Hotels in San Diego
- Hotels in Branson
- Hotels with Parking in Cape Girardeau
- Hotels in Boone
- Cheap Hotels in Twin Falls
- Cheap Hotels in Kirksville
- Hotels in Weston
- Hotels in Emerald Isle
- Hotels with Free Breakfast in Warrenton
- Hotels with Parking in Ironwood
- Hotels in Linn
- Hotels in Big Spring
- Family Hotels in Lebanon
- Hotels in Laconia
- Cheap Hotels in Biloxi
- Family Hotels in Colby
- Hotels in Lawrenceville
- Hotels in Neenah
- Hotels in McAllen
- Cheap Hotels in Hampton
- Hotels in Pella
- Cheap Hotels in Dothan
- Hotels in Anaheim
- Hotels in South Lake Tahoe
- Hotels in Sikeston
- Hotels with a Pool in Camdenton
- Business Hotels in Hannibal
- Hotels in Lake Ozark
- Hotels in Bolivar
- Cheap Hotels in Branson