Hotels in East Prairie

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Check prices for these dates

Tonight
Apr 28 - Apr 29
Tomorrow
Apr 29 - Apr 30
This weekend
May 1 - May 3
Next weekend
May 8 - May 10

Where to stay in East Prairie?

Suite, 2 Queen Beds, Non Smoking | Individually furnished, desk, laptop workspace, blackout drapes
MainStay Suites at Discovery Park of America
MainStay Suites at Discovery Park of America
2.5 star property
Union City
8.8 out of 10, Excellent, (46 reviews)
Explore Union City from this welcoming hotel with 24-hour fitness amenities and convenient hiking trails in the area. Near Kiwanis Park and Masquerade Theatre, you'll enjoy free breakfast, WiFi, and parking while rooms offer refrigerators and microwaves.
The price is $107
$127 total
includes taxes & fees
May 10 - May 11
MainStay Suites at Discovery Park of America
Lobby
Sleep Inn at Discovery Park of America
Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (383 reviews)
Slip into this inviting Union City hotel just minutes from Discovery Park of America's interactive exhibits. After exploring nearby attractions, unwind in the refreshing indoor pool or maintain your routine in the 24-hour fitness center. Free breakfast, WiFi and parking enhance your value-packed stay.
The price is $79
$94 total
includes taxes & fees
May 19 - May 20
Sleep Inn at Discovery Park of America
Lobby
Hospitality House Union City I 69 / US 51
Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (391 reviews)
Discover this Union City hotel offering a seasonal outdoor pool and onsite restaurant. Free breakfast, WiFi, and parking add convenience. Visitors appreciate the helpful staff and proximity to County Market Place and Reelfoot Shopping Center.
The price is $57
$68 total
includes taxes & fees
Apr 29 - Apr 30
Hospitality House Union City I 69 / US 51
Exterior
Holiday Inn Express & Suites Union City by IHG
Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (321 reviews)
Relax in this Union City hotel where the 24-hour fitness center keeps you energized. Free breakfast, WiFi, and parking await near Discovery Park of America. After exploring nearby attractions, return to rooms praised by guests for comfort and service.
The price is $115
$137 total
includes taxes & fees
May 17 - May 18
Holiday Inn Express & Suites Union City by IHG
Lobby
Country Hearth Inn & Suites Union City
Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (567 reviews)
Inviting comfort awaits at this Union City motel where complimentary continental breakfast starts your day. Located near County Market Place and Reelfoot Shopping Center, enjoy free WiFi and parking with attentive staff ready to assist you.
The price is $67
$80 total
includes taxes & fees
May 5 - May 6
Country Hearth Inn & Suites Union City
Terrace/patio
Hampton Inn Union City
Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (180 reviews)
Minutes from County Market Place, this hotel offers a welcoming indoor pool, fitness center, and free breakfast. Guests rave about the helpful staff, while free parking makes exploring easy. Reelfoot Shopping Center is nearby for retail therapy.
The price is $107
$127 total
includes taxes & fees
May 24 - May 25
Hampton Inn Union City
Free buffet breakfast
Quality Inn Union City US 51
Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (504 reviews)
This Quality Inn offers a seasonal outdoor pool, rejuvenating hot tub, and complimentary breakfast near County Market Place. With free WiFi, parking, and easy access to Reelfoot Shopping Center, travelers appreciate the attentive staff.
The price is $67
$80 total
includes taxes & fees
May 24 - May 25
Quality Inn Union City US 51
Lobby
Quality Inn Cairo I-57
Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (284 reviews)
Set off I-57 in Cairo, this welcoming hotel provides complimentary full breakfast and self parking. Explore nearby Fort Defiance State Park or take a short drive to Ballard Wildlife Management Area while enjoying free WiFi throughout your stay.
The price is $77
$85 total
includes taxes & fees
May 5 - May 6
Quality Inn Cairo I-57
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston
Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
Active travelers will appreciate the health club at this comfortable Charleston motel. Free WiFi keeps you connected, while complimentary parking saves you money. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
The price is $55
$61 total
includes taxes & fees
May 2 - May 3
Eagle Inn Charleston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (630 reviews)
This Charleston motel offers complimentary WiFi, parking, and on-the-go breakfast daily. Located with convenient interstate access to Cape Girardeau, guests consistently praise the helpful staff. The comfortable accommodations provide a practical base for exploring southeastern Missouri.
The price is $63
$70 total
includes taxes & fees
May 3 - May 4
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby sitting area
The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
The price is $75
$83 total
includes taxes & fees
Apr 29 - Apr 30
The Riverstone Hotel Charleston-Sikeston
Standard Room, 2 Double Beds, Non Smoking | Blackout drapes, iron/ironing board, free WiFi, bed sheets
Reelfoot Lake Inn
Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (482 reviews)
The price is $70
$80 total
includes taxes & fees
Apr 29 - Apr 30
Reelfoot Lake Inn
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite
Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (135 reviews)
This welcoming motel offers convenience with complimentary WiFi and parking, plus round-the-clock front desk assistance. Explore nearby Central Park and Sikeston Depot Museum before returning to your comfortable accommodations.
The price is $63
$75 total
includes taxes & fees
Apr 29 - Apr 30
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,003 reviews)
Travelers rave about this serene retreat with helpful staff and clean rooms. Take advantage of free WiFi, parking, and on-the-go breakfast. Work out in the fitness center before exploring Central Park and Sikeston Depot Museum nearby.
The price is $68
$78 total
includes taxes & fees
May 3 - May 4
Days Inn and Suites by Wyndham Sikeston
Free daily full breakfast
Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,000 reviews)
Experience comfort at this Sikeston hotel, offering free breakfast and parking close to Central Park. The helpful staff welcomes guests to enjoy the indoor pool and fitness center. With easy access to Sikeston Depot Museum, you'll find everything needed for a convenient Missouri stay.
The price is $80
$91 total
includes taxes & fees
May 20 - May 21
Best Western Plus Sikeston I-55
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,007 reviews)
Escape to this serene Sikeston hotel with both indoor and outdoor pools near restaurants and shopping. The fitness center, free breakfast, WiFi and parking enhance your stay, while the helpful staff ensures comfort just minutes from Central Park.
The price is $102
$117 total
includes taxes & fees
May 4 - May 5
Drury Inn & Suites Sikeston, MO
Individually decorated, individually furnished, desk, blackout drapes
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (769 reviews)
This peaceful hotel offers a complimentary continental breakfast, free WiFi, and convenient parking. Located near I-55 Exit 67, guests consistently praise the helpful staff and clean rooms that provide a quiet retreat after exploring local attractions.
The price is $65
$74 total
includes taxes & fees
May 12 - May 13
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (293 reviews)
Warm comfort awaits at this Sikeston hotel where the indoor pool invites morning swims. Just minutes from Central Park and Sikeston Depot Museum, enjoy free WiFi, parking, and a fitness center while helpful staff enhance your stay.
The price is $93
$106 total
includes taxes & fees
May 20 - May 21
Comfort Inn & Suites Sikeston I-55
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (461 reviews)
Experience Sikeston from this hotel with free breakfast, WiFi, and parking. Take a morning dip in the indoor pool or hit the fitness center. Near Central Park and Sikeston Depot Museum, guests love the helpful staff and clean rooms.
The price is $105
$119 total
includes taxes & fees
May 3 - May 4
Holiday Inn Express & Suites Sikeston Southwest by IHG
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (615 reviews)
Cozy lodging near Central Park and Sikeston Depot Museum with complimentary breakfast, WiFi, and parking. Just 29 minutes from Cape Girardeau Municipal Airport, this Super 8 offers comfortable accommodations for exploring the area.
The price is $63
$72 total
includes taxes & fees
May 3 - May 4
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in East Prairie

Big Oak Tree State Park

4.0/5 (20 reviews)
Big Oak Tree State Park is 10.3 mi (16.6 km) from central East Prairie, why not stop by during your stay.
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Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Check out reviews of East Prairie hotels guests love

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"It was amazing thank you"
Tonnie 1-night trip
Posted 18 hours ago
Super 8 by Wyndham Sikeston/Miner Area

Frequently asked questions

What hotels do travelers like in East Prairie?
Guests like Quality Inn Charleston - Sikeston.
Can I book a refundable hotel in East Prairie?
If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in East Prairie be like during my trip?
July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.
Why should I book my East Prairie accommodation with Hotels.com?
There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.