Hotels in East Prairie

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Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (620 reviews)
  • cleanliness
    Gateway to historic Charleston with easy interstate access and free breakfast.
The price is $62
$69 total
includes taxes & fees
Jan 20 - Jan 21
Super 8 by Wyndham Charleston/Sikeston East MO
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,005 reviews)
  • cleanliness
    Peaceful highway-adjacent retreat with indoor and outdoor pool options.
The price is $94
$108 total
includes taxes & fees
Jan 25 - Jan 26
Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,003 reviews)
  • cleanliness
    Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.
The price is $71
$81 total
includes taxes & fees
Jan 25 - Jan 26
Best Western Plus Sikeston
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1,006 reviews)
  • cleanliness
    Quiet, dual pool paradise near Central Park in charming Sikeston.
The price is $75
$86 total
includes taxes & fees
Jan 25 - Jan 26
Pear Tree Inn Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (731 reviews)
  • cleanliness
    Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.
The price is $58
$67 total
includes taxes & fees
Jan 20 - Jan 21
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (284 reviews)
  • cleanliness
    Cozy stay near Central Park with indoor pool, free WiFi, and friendly staff.
The price is $84
$96 total
includes taxes & fees
Jan 24 - Jan 25
Comfort Inn & Suites Sikeston I-55
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (463 reviews)
  • cleanliness
    Discover contemporary comfort with an indoor pool just off I-55 in Sikeston.
The price is $100
$114 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (50 reviews)
  • cleanliness
    Discover a modern retreat with a welcoming indoor pool and sip drinks at the bar.
The price is $101
$114 total
includes taxes & fees
Jan 29 - Jan 30
Fairfield Inn & Suites by Marriott Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,003 reviews)
  • cleanliness
    Enjoy a peaceful night's rest and complimentary breakfast at this quiet Sikeston hotel.
The price is $63
$72 total
includes taxes & fees
Jan 25 - Jan 26
Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (446 reviews)
  • cleanliness
    Convenient stay near Central Park with refreshing pool and complimentary perks.
The price is $93
$105 total
includes taxes & fees
Jan 25 - Jan 26
Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (584 reviews)
  • cleanliness
    Convenient Sikeston escape with free amenities and easy access to local attractions.
The price is $59
$68 total
includes taxes & fees
Jan 20 - Jan 21
Super 8 by Wyndham Sikeston/Miner Area
Eagle Inn Charleston
Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
  • cleanliness
    Stay fit while visiting Charleston with a health club at this convenient motel.
The price is $60
$67 total
includes taxes & fees
Jan 20 - Jan 21
Eagle Inn Charleston
TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (12 reviews)
The price is $114
$129 total
includes taxes & fees
Jan 25 - Jan 26
TownePlace Suites by Marriott Sikeston
Country Yard Inn and Suite
Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121 reviews)
  • cleanliness
    Enjoy a comfortable base in Sikeston with free perks and 24-hour service.
The price is $65
$77 total
includes taxes & fees
Jan 20 - Jan 21
Country Yard Inn and Suite
Quality Inn Cairo I-57
Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (275 reviews)
  • cleanliness
    Convenient Cairo hotel offers comfortable stay with free breakfast and WiFi.
The price is $71
$79 total
includes taxes & fees
Jan 31 - Feb 1
Quality Inn Cairo I-57
Super 8 By Wyndham Marston
Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (43 reviews)
  • cleanliness
    Welcoming roadside retreat with quick access to I-55 and daily breakfast service.
The price is $56
$64 total
includes taxes & fees
Jan 20 - Jan 21
Super 8 By Wyndham Marston
Travel Inn
Travel Inn
2.5 star property
Marston
6.0 out of 10, (116 reviews)
The price is $45
$51 total
includes taxes & fees
Jan 20 - Jan 21
Travel Inn
Reelfoot Lake Inn
Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (465 reviews)
The price is $46
$53 total
includes taxes & fees
Feb 19 - Feb 20
Reelfoot Lake Inn
Sleep Inn at Discovery Park of America
Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (332 reviews)
  • cleanliness
    Wake up to historic adventure at this convenient Union City hotel near Discovery Park.
The price is $81
$96 total
includes taxes & fees
Feb 8 - Feb 9
Sleep Inn at Discovery Park of America
Holiday Inn Express & Suites Union City by IHG
Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.2 out of 10, Wonderful, (312 reviews)
  • cleanliness
    Take a morning dip in the indoor pool, steps from entertainment district.
The price is $104
$124 total
includes taxes & fees
Feb 6 - Feb 7
Holiday Inn Express & Suites Union City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in East Prairie

Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

Bridge over Mississippi River, New Orleans in background

Check out reviews of East Prairie hotels guests love

Frequently asked questions

What hotels do travelers like in East Prairie?
Can I book a refundable hotel in East Prairie?
If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in East Prairie be like during my trip?
July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.
Why should I book my East Prairie accommodation with Hotels.com?
There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.