Top 10 Hotels in Vance, SC in 2026 (from $54)

A river with a dam and a bridge, surrounded by greenery and fields.

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Where to stay in Vance?

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A gym with treadmills, weight machines, and a wall of dumbbells.

1. Hampton Inn Santee-I-95

Santee

$110

$122 total

includes taxes & fees

Oct 11 - Oct 12

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A modern lobby with a blue sofa, teal chairs, and a wooden table.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

2. Tru By Hilton Santee

Santee

$101

$112 total

includes taxes & fees

Oct 18 - Oct 19

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A modern restaurant with a central island, multiple seating areas, and a large window providing natural light.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

3. Fairfield Inn & Suites by Marriott Santee

Santee

$139

$154 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A Baymont by Wyndham hotel with a blue and yellow facade, a covered parking area, and a large parking lot.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

4. Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Oct 5 - Oct 6

A hotel entrance with a sign reading "Best Western PLISS."

A spacious living room with a large window, a ceiling fan, and a vibrant red accent wall.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

5. Best Western Plus Santee Inn

Santee

$131

$145 total

includes taxes & fees

Oct 14 - Oct 15

A water park with a pool, slides, and umbrellas.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a wooden panel backdrop and a neon sign.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

6. Holiday Inn Santee by IHG

Santee

$104

$115 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with a sofa, a red ottoman, a TV mounted on the wall, and a wooden entertainment unit.

7. Comfort Inn & Suites Santee

Santee

$106

$117 total

includes taxes & fees

Nov 1 - Nov 2

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A living room with a brown sofa set, a wooden coffee table, and a chandelier.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

8. Quality Inn & Suites Santee I-95

Santee

$54

$65 total

includes taxes & fees

Oct 25 - Oct 26

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A two-story building with a beige facade, large windows, and a central entrance.

9. Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A bathroom with a granite countertop, a sink, a mirror, and a light fixture above the mirror.

A kitchen with a countertop, cabinets, a microwave, and a sink.

10. Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Oct 18 - Oct 19

A vending machine with various snacks and drinks, including Pepsi, and a water dispenser labeled 'Ice Cubes'.

A hotel room with a dining area, a TV screen displaying 'Free Wi-Fi All Rooms,' and a kitchen area.

A hotel lobby with a reception desk, a dining area with tables and chairs, and a view of the outside.

A small, single-story building with a blue exterior and a sign that reads 'Cypress Landing State Park.'

11. Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Oct 7 - Oct 8

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A modern room with a grey sofa, a small table, and a view of a lake and parked car through large glass doors.

A compact living space with a bunk bed, a kitchenette, and a control panel with a clock.

A tent with two beds, a small table, and a chair.

12. Bells Marina & Resort

Eutawville

$85

$97 total

includes taxes & fees

Nov 2 - Nov 3

A two-story building with a sign reading "PachTree Inn".

A compact hotel room with a kitchenette, a television, a desk, and a chair.

A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.

A hotel room with two beds, a nightstand, a lamp, a chair, and a painting on the wall.

13. Peach Tree Inn

St. George

$58

$63 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A reception area with a counter, framed pictures, and a clock on the wall.

A bathroom with a sink, mirror, and a shower area.

14. Econo Lodge Santee

Santee

$68

$75 total

includes taxes & fees

Nov 1 - Nov 2

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

15. Ramada by Wyndham Santee I-95

Santee

$87

$97 total

includes taxes & fees

Oct 12 - Oct 13

A fire extinguisher, a water dispenser, a staircase, and a laundry area.

A hotel room with a bed, a round table, two chairs, a window with curtains, and an air conditioning unit.

A multi-story motel with a covered parking area and a staircase leading to the entrance.

A bedroom with a bed, bedside tables, a mirror, a door, and a wall-mounted telephone.

16. Ashburn Inn Manning I 95

Manning

$62

$69 total

includes taxes & fees

Oct 5 - Oct 6

A buffet with various food items and utensils.

A room with a patterned carpet, two potted plants, a wooden shelf with books, and a door with a sign.

A room with a sofa, a small table, a chair, and a patterned rug.

A reception area with a counter, a clock, a ceiling fan, and a potted plant.

17. Sunset Inn Manning I 95

Summerton

$54

$66 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a bed, a black armchair, a round mirror with lights, a black vanity with a sink, and a white towel on the wall.

A modern room with a grey sofa, a small table, and a black countertop with a sink.

A building with a red roof and a covered entrance area. There are cars parked in front.

A bathroom with a textured wall, a round mirror with a light, a black countertop, and a white sink.

18. Starlight Stays

Manning

$68

$75 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a bed, a desk, a chair, a TV, and artwork on the wall.

A spacious lobby with a reception desk, seating area, and large windows offering views of the outdoors.

A spacious indoor area with a reception desk, several wooden chairs, a large potted plant, and a view through large windows.

A compact room with a wooden desk, a yellow chair, a flat-screen TV, a refrigerator, a microwave, and a small seating area with a blue cushion.

19. Days Inn by Wyndham St George

St. George

$100

$111 total

includes taxes & fees

Oct 9 - Oct 10

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

A workspace with two desks, each with a computer monitor, keyboard, and chair.

A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.

20. Fairfield Inn by Marriott Orangeburg

Orangeburg

$101

$112 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Go beyond your typical stay in Vance

Learn more about Vance

The region around Vance is home to attractions such as Lake Marion and Santee Cooper Country Club.

See all hotels in Vance

Check out reviews of Vance hotels guests love

Hampton Inn Santee-I-95

Santee

10/10 Exceptional

Michael

Fairfield Inn & Suites by Marriott Santee

Santee

10/10 Exceptional

Fairfield Inn by Marriott Orangeburg

Orangeburg

10/10 Exceptional

Barry

A Red Roof Inn with a simple facade, a covered entrance, and a parking lot in front.

A Red Roof Inn with a clear sky, a well-maintained lawn, and a parking lot.

A hotel room with two beds, a desk, and a chair.

A hotel lobby with a large sliding glass door, a reception desk, a seating area with red chairs, and a stone accent wall.

Red Roof Inn St George, SC

St. George

10/10 Exceptional

The overall quality for this hotel was great. The interior was very up to date and it seemed clean for the most part. The only weird/inconvenient thing about this place is that check in was 3 and when we got to our room it still had not been cleaned but there was clean bedding thrown into a pile on the bed. So we just made the bed and put the full trash can from the previous stay outside of the door and the staff emptied it eventually. I would definitely stay here again and I recommend this...

Anonymous traveler

Frequently Asked Questions

What hotels do travelers recommend in Vance?

Guests like Tru By Hilton Santee, Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee.

Can I book a refundable accommodation in Vance?

If you want the flexibility to change your travel plans to Vance, most hotels provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Vance be like during my visit?

July and August are typically the warmest months in Vance when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.

Why should I book my Vance hotel with Hotels.com?

There are lots of reasons to book your Vance trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.