Top 10 Hotels in Saint Matthews, SC in 2026 (from $55)

Q: What hotels do travelers like in Saint Matthews?

Guests like Tru by Hilton Orangeburg .

A swamp with tall trees and water reflecting the greenery.

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Where to stay in Saint Matthews?

A modern interior with a dining area, seating, and a kitchen.

1. Tru by Hilton Orangeburg

Orangeburg

$122 total

includes taxes & fees

Nov 29 - Nov 30

A modern indoor pool area with a table and chairs, large windows, and a poolside lounge with sun loungers.

2. Spark by Hilton Orangeburg

Orangeburg

$99 total

includes taxes & fees

Nov 29 - Nov 30

A spacious dining area with multiple tables and chairs, a reception desk, and large windows providing natural light.

3. SpringHill Suites by Marriott Orangeburg

Orangeburg

$121 total

includes taxes & fees

Nov 23 - Nov 24

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

4. Fairfield Inn by Marriott Orangeburg

Orangeburg

$112 total

includes taxes & fees

Nov 22 - Nov 23

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

5. Hampton Inn & Suites Orangeburg

Orangeburg

$150 total

includes taxes & fees

Dec 13 - Dec 14

A breakfast bar with pastries, fruits, and a vase with flowers.

6. Travelodge by Wyndham Orangeburg

Orangeburg

$74 total

includes taxes & fees

Nov 15 - Nov 16

A Holiday Inn Express & Suites hotel with a prominent sign, a central entrance, and a symmetrical facade.

7. Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

$131 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a sofa, chairs, a coffee table, and a staircase with a green leaf-patterned wall.

8. Sleep Inn Orangeburg

Orangeburg

$97 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

9. Quality Inn & Suites Orangeburg

Orangeburg

$64 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with two beds, a desk, and a chair. There are wall-mounted lamps and a large window with curtains.

10. Comfort Inn & Suites Orangeburg

Orangeburg

$112 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with two beds, a desk, a chair, and a wall-mounted lamp.

11. Red Roof Inn Orangeburg

Orangeburg

$65 total

includes taxes & fees

Nov 22 - Nov 23

A modern kitchen with a long counter, equipped with coffee makers, a kettle, and a microwave.

12. Super 8 by Wyndham, Orangeburg

Orangeburg

$65 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, a desk, a chair, a sofa, and a table.

13. Baymont by Wyndham Orangeburg North

Orangeburg

$61 total

includes taxes & fees

Nov 29 - Nov 30

A restaurant with round tables and chairs, a counter with a display case, and large windows.

14. Southern Lodge 601

Orangeburg

$75 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, a desk, a chair, and a hanging coat rack.

15. Suburban Studios Orangeburg

Orangeburg

$69 total

includes taxes & fees

Nov 22 - Nov 23

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

16. Tru By Hilton Santee

Santee

$117 total

includes taxes & fees

Nov 29 - Nov 30

A hotel room with a bed, bedside table, lamp, and a mirror.

17. Baymont by Wyndham Santee

Santee

$89 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a sofa, a bed with a red blanket, two bedside lamps, a small table, and a TV.

18. Orangeburg Inn & Suites

Orangeburg

$61 total

includes taxes & fees

Nov 15 - Nov 16

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

19. Fairfield Inn & Suites by Marriott Santee

Santee

$149 total

includes taxes & fees

Dec 7 - Dec 8

An outdoor patio with a stone fire pit, seating, and a covered area with lights.

20. Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

$107 total

includes taxes & fees

Nov 22 - Nov 23

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Go beyond your typical stay in Saint Matthews

Learn more about Saint Matthews

The region around Saint Matthews is home to attractions such as Congaree National Park and Harry Hampton Visitor Center.

See all hotels in Saint Matthews

Check out reviews of Saint Matthews hotels guests love

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

Kevin

Holiday Inn Express & Suites Orangeburg by IHG

Orangeburg

10/10 Exceptional

Deborah

Fairfield Inn & Suites by Marriott Santee

Santee

10/10 Exceptional

Choose this hotel for a pet-friendly stop-over on our drive to Florida and had a great experience. This staff was super-friendly and this nearly-brand-new property was immaculate. They have us a great 1st floor room with easy access to the walking and parking area. We took advantage of the patio to have dinner (take-out from a local restaurant) and breakfast with our dog. The breakfast was excellent, including hot omelets, eggs, and sausage, and the 6 am start (on a Sunday) allowed us to get...

Douglas

Fairfield Inn by Marriott Orangeburg

Orangeburg

10/10 Exceptional

Barry

Comfort Inn & Suites Orangeburg

Orangeburg

10/10 Exceptional

Ken

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

Hampton Inn Santee-I-95

Santee

10/10 Exceptional

Michael

Tru By Hilton Santee

Santee

10/10 Exceptional

Rebecca

Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

10/10 Exceptional

Savannah

A hotel entrance with a sign reading "Best Western PLISS."

Best Western Plus Santee Inn

Santee

10/10 Exceptional

Richard

A modern living room with a blue cabinet, a blue sofa, a round coffee table, and patterned ottomans.

Hotel Trundle

Downtown Columbia

10/10 Exceptional

Loretta

An outdoor patio with yellow chairs and tables, a pergola with string lights, and a stone wall.

Home2 Suites by Hilton Columbia Southeast Fort Jackson

Columbia

10/10 Exceptional

Jodi

A spacious indoor area with a long table, multiple chairs, and a seating area with sofas and a TV.

The Lantern Hotel Columbia

Downtown Columbia

10/10 Exceptional

jill

A modern kitchen with a long counter, a coffee machine, and a refrigerator.

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

Columbia

10/10 Exceptional

Rosa

An indoor swimming pool with a diving board, tiled flooring, and a seating area with tables and chairs.

Holiday Inn Express & Suites Columbia-Fort Jackson by IHG

Columbia

10/10 Exceptional

Raphael

An outdoor patio with a stone fire pit, a grill, and red umbrellas.

TownePlace Suites by Marriott Columbia Southeast/Ft Jackson

Columbia

10/10 Exceptional

Michael

Frequently Asked Questions

What hotels do travelers like in Saint Matthews?

Guests like Tru by Hilton Orangeburg.

Can I book a refundable hotel in Saint Matthews?

If you want the flexibility to change your travel plans to Saint Matthews, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Saint Matthews be like during my trip?

July and August are typically the warmest months in Saint Matthews when the average temp is 79°F. January and February are the coldest months when the average temperature is 51°F. August and July are the months with the most rain.

Why should I book my Saint Matthews accommodation with Hotels.com?

There are lots of reasons to book your Saint Matthews trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.