Hotels in Saint Matthews

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Next weekend

Where to stay in Saint Matthews?

Travelodge by Wyndham Orangeburg
Travelodge by Wyndham Orangeburg
2.0 star property
Orangeburg
8.2 out of 10, Very Good, (1,004 reviews)
  • cleanliness
    Modern Orangeburg stay with free WiFi and parking, near local attractions.
The price is $75
$83 total
includes taxes & fees
Mar 5 - Mar 6
Travelodge by Wyndham Orangeburg
Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,437 reviews)
  • cleanliness
    Relax in peaceful Santee with continental breakfast and helpful staff nearby.
The price is $80
$89 total
includes taxes & fees
Mar 5 - Mar 6
Baymont by Wyndham Santee
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,006 reviews)
The price is $112
$124 total
includes taxes & fees
Mar 8 - Mar 9
Best Western Plus Santee Inn
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,009 reviews)
  • cleanliness
    Comfortable hotel in a tranquil setting, perfect for morning swims and golf outings.
The price is $125
$139 total
includes taxes & fees
Mar 22 - Mar 23
Fairfield Inn & Suites by Marriott Santee
Comfort Inn & Suites Orangeburg
Comfort Inn & Suites Orangeburg
2.5 star property
Orangeburg
8.0 out of 10, Very Good, (582 reviews)
  • cleanliness
    Comfort and convenience minutes away from Smith-Hammond-Middleton Memorial Center.
The price is $98
$109 total
includes taxes & fees
Mar 10 - Mar 11
Comfort Inn & Suites Orangeburg
Tru By Hilton Santee
Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (747 reviews)
  • cleanliness
    Experience a comfortable stay near Santee Cooper Country Club with top-rated service.
The price is $114
$127 total
includes taxes & fees
Mar 10 - Mar 11
Tru By Hilton Santee
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (444 reviews)
  • cleanliness
    Enjoy a peaceful golf escape at this quiet Santee motel with seasonal pool.
The price is $75
$83 total
includes taxes & fees
Mar 5 - Mar 6
Super 8 by Wyndham Santee
Motel 6 West Columbia, SC - Airport
Motel 6 West Columbia, SC - Airport
2.0 star property
West Columbia
7.6 out of 10, Good, (511 reviews)
  • cleanliness
    Central location near Columbia's airport with free WiFi and convenient parking.
The price is $66
$71 total
includes taxes & fees
Mar 5 - Mar 6
Motel 6 West Columbia, SC - Airport
Orangeburg Inn & Suites
Orangeburg Inn & Suites
2.0 star property
Orangeburg
6.0 out of 10, (60 reviews)
  • cleanliness
    Enjoy comfort and easy access to Orangeburg's local attractions at this welcoming inn.
The price is $54
$61 total
includes taxes & fees
Mar 5 - Mar 6
Orangeburg Inn & Suites
Spark by Hilton Orangeburg
Spark by Hilton Orangeburg
2.5 star property
Orangeburg
7.8 out of 10, Good, (1,004 reviews)
  • cleanliness
    Central stay in Orangeburg with seasonal pool and complimentary breakfast.
The price is $103
$115 total
includes taxes & fees
Mar 8 - Mar 9
Spark by Hilton Orangeburg
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (703 reviews)
The price is $63
$70 total
includes taxes & fees
Mar 5 - Mar 6
Travelodge by Wyndham Santee
Baymont by Wyndham Orangeburg North
Baymont by Wyndham Orangeburg North
2.5 star property
Orangeburg
6.0 out of 10, (1,004 reviews)
  • cleanliness
    Perfect spot in Orangeburg with seasonal pool, free breakfast, and parking.
The price is $59
$65 total
includes taxes & fees
Mar 10 - Mar 11
Baymont by Wyndham Orangeburg North
Southern Lodge 601
Southern Lodge 601
Orangeburg
2.0 out of 10, (1 review)
The price is $76
$84 total
includes taxes & fees
Mar 5 - Mar 6
Southern Lodge 601
Quality Inn & Suites Orangeburg
Quality Inn & Suites Orangeburg
2.5 star property
Orangeburg
6.2 out of 10, (642 reviews)
  • cleanliness
    Affordable Orangeburg hotel with free amenities near dining and attractions.
The price is $63
$70 total
includes taxes & fees
Mar 10 - Mar 11
Quality Inn & Suites Orangeburg
SpringHill Suites by Marriott Orangeburg
SpringHill Suites by Marriott Orangeburg
2.5 star property
Orangeburg
8.8 out of 10, Excellent, (708 reviews)
  • cleanliness
    Relax by the indoor pool near I.P. Stanback Museum in this convenient Orangeburg stay.
The price is $105
$116 total
includes taxes & fees
Mar 10 - Mar 11
SpringHill Suites by Marriott Orangeburg
Holiday Inn Express & Suites Orangeburg by IHG
Holiday Inn Express & Suites Orangeburg by IHG
2.5 star property
Orangeburg
8.6 out of 10, Excellent, (813 reviews)
  • cleanliness
    Stay steps from Columbia and enjoy free perks at this convenient Orangeburg hotel.
The price is $134
$149 total
includes taxes & fees
Mar 15 - Mar 16
Holiday Inn Express & Suites Orangeburg by IHG
Super 8 by Wyndham, Orangeburg
Super 8 by Wyndham, Orangeburg
2.0 star property
Orangeburg
6.8 out of 10, (922 reviews)
  • cleanliness
    Cozy and convenient motel near Orangeburg attractions with complimentary breakfast.
The price is $58
$64 total
includes taxes & fees
Mar 10 - Mar 11
Super 8 by Wyndham, Orangeburg
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,003 reviews)
The price is $124
$137 total
includes taxes & fees
Mar 10 - Mar 11
Hampton Inn Santee-I-95
Baymont by Wyndham Columbia Fort Jackson
Baymont by Wyndham Columbia Fort Jackson
2.5 star property
Columbia
5.8 out of 10, (1,003 reviews)
  • cleanliness
    Modern hotel near Fort Jackson, offering fitness and outdoor pool for relaxation.
The price is $64
$71 total
includes taxes & fees
Mar 15 - Mar 16
Baymont by Wyndham Columbia Fort Jackson
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1,005 reviews)
  • cleanliness
    Relax in a serene hotel with a seasonal outdoor pool near Santee attractions.
The price is $104
$115 total
includes taxes & fees
Mar 10 - Mar 11
Comfort Inn & Suites Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Saint Matthews

The region around Saint Matthews is home to attractions such as Congaree National Park and Harry Hampton Visitor Center.

Moss Covered Cypress Trees Stand Tall in A Dark Marsh Of Congaree

Check out reviews of Saint Matthews hotels guests love

Frequently asked questions

What hotels do travelers like in Saint Matthews?
Can I book a refundable hotel in Saint Matthews?
If you want the flexibility to change your travel plans to Saint Matthews, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Saint Matthews be like during my trip?
July and August are typically the warmest months in Saint Matthews when the average temp is 79°F. January and February are the coldest months when the average temperature is 51°F. August and July are the months with the most rain.
Why should I book my Saint Matthews accommodation with Hotels.com?
There are lots of reasons to book your Saint Matthews trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.