Hotels in Wykoff

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Where to stay in Wykoff?

A lobby with leather sofas, a reception desk, a clock, and a map of the museum.

A breakfast room with wooden tables and chairs, a coffee machine, and a view of the outdoors.

A hotel room with a large bed, a separate bathroom with a bathtub, a bedside table with a lamp, and a framed picture on the wall.

A lobby with a fireplace, leather seating, a television, and a large window.

1. Americas Best Value Inn & Suites Spring Valley

Spring Valley

$89

$98 total

includes taxes & fees

Oct 13 - Oct 14

A hotel room with two beds, a desk, a chair, and a lamp.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

A swimming pool with a capacity sign, a lifeguard warning sign, and a spa rules sign.

2. Country Trails Inn & Suites

Preston

$126

$140 total

includes taxes & fees

Oct 13 - Oct 14

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

A rustic bar area with wooden beams, a wooden counter, and sacks of grain.

3. Stone Mill Hotel & Suites

Lanesboro

$105

$113 total

includes taxes & fees

Oct 18 - Oct 19

A multi-story building with a balcony, surrounded by various potted plants and flowers.

A porch with a variety of potted plants and flowers, a sign reading "OFFICE Welcome to Green Gables," and a door with a green doorbell.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

A bedroom with a four-poster bed, a sofa, a desk, and a fireplace.

4. Green Gables Inn

Lanesboro

$111

$119 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A gym with treadmills, elliptical machines, and a stationary bike.

A modern living room with a sofa, two armchairs, a coffee table, and a large window offering a view of the outdoors.

5. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

$80

$92 total

includes taxes & fees

Nov 10 - Nov 11

A reception desk with a wooden finish, a glass partition, and a blue wall with climbing plants.

A dining area with wooden tables and chairs, a brick fireplace, and a television mounted above it.

A hotel with a parking lot, a yellow food truck, and several cars parked.

A hotel room with two beds, each with white linens and patterned bedspreads. There are bedside tables with lamps, a desk with a chair, and a wall-mounted TV.

6. America's Stay Inn Stewartville

Stewartville

$70

$78 total

includes taxes & fees

Oct 13 - Oct 14

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A small, well-organized pantry with shelves stocked with snacks and beverages.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

7. Spark by Hilton Rochester South

Rochester

$84

$97 total

includes taxes & fees

Nov 8 - Nov 9

A modern hotel lobby with a reception desk, seating area, and a dining space.

A Holiday Inn Express building with a stone facade and illuminated signage.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

8. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

$94

$108 total

includes taxes & fees

Nov 12 - Nov 13

A hotel room with a large bed, a desk with a television, a chair, and a wardrobe.

A hotel room with two beds, a desk, a chair, and a mirror.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

A bar with wooden stools and a neon sign.

9. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

$73

$84 total

includes taxes & fees

Oct 17 - Oct 18

A bedroom with a sloped ceiling, a brick wall, a bed with floral bedding, two bedside lamps, and a vase with red flowers.

A living room with a brick wall, a television, a refrigerator, and a coffee table.

A building with a covered porch, a swing set, and a bird sculpture.

A compact living space with a kitchenette, a dining area, and a sofa.

10. Country Lodge inn

Harmony

$146

$168 total

includes taxes & fees

Oct 13 - Oct 14

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

A hotel reception area with wooden reception desks, a cityscape mural on the wall, and a check-in counter with a bookshelf.

11. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

$73

$84 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bed, a television, a desk, and a window with curtains.

A lobby with two leather armchairs, a welcome sign, and a lamp on a small table.

A compact kitchen with a refrigerator, microwave, and sink. There's a small dining table with a chair.

A hotel lobby with a reception desk, a 'WELCOME' sign, a seating area, and a buffet counter.

12. MainStay Suites Rochester South Mayo Clinic

Rochester

$61

$70 total

includes taxes & fees

Oct 18 - Oct 19

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

13. Econo Lodge Mayo Clinic Area

Rochester

$67

$77 total

includes taxes & fees

Nov 8 - Nov 9

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

14. Quality Inn & Suites Mayo Clinic Area

Rochester

$73

$86 total

includes taxes & fees

Nov 6 - Nov 7

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

15. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

$122

$154 total

includes taxes & fees

Oct 17 - Oct 18

16. Birch Hill Suite Rochester – Med City

Rochester

$64

$74 total

includes taxes & fees

Oct 13 - Oct 14

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

An outdoor dining area with wooden beams, tables, and chairs.

17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

$107

$123 total

includes taxes & fees

Oct 24 - Oct 25

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern hotel room with a bed, desk, and kitchenette.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

18. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

$127

$146 total

includes taxes & fees

Oct 24 - Oct 25

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

A coffee station with two espresso machines and a variety of coffee pods and cups.

19. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

$110

$127 total

includes taxes & fees

Oct 17 - Oct 18

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

20. Hampton Inn Rochester-South

Rochester

$110

$126 total

includes taxes & fees

Oct 18 - Oct 19

View all properties

Go beyond your typical stay in Wykoff

Pet friendly

Pool

Hot tub

Family friendly

Top landmarks in Wykoff

Ed's Museum

If museums are on your list of things to see, then you might want to head to Ed's Museum, located in the heart of Wykoff.

See properties

Check out reviews of Wykoff hotels guests love

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Room itself was clean some dishes were dirty but they supplied dish soap and dish washing powder so it was an easy fix. Towels were switched out regularly along with trash taken out regularly. Hallways were clean. Sometimes a faint odor of smoke in the halls but otherwise not a bad place. Staff were helpful whenever the key cards stopped working. View from specific room was mediocre at best was mostly the roof of the pool area."

Brentwood Inn & Suites

8/10 Good

"I definitely recommend staying at the Brentwood if you have Mayo apts . Free parking, clean rooms, excellent staff, and of course location make this a great place. I would recommend too if your just on holiday in Rochester because of the shops and other bustling activity around."

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"Decent with a good price including breakfast for a 2 days trip to Rochester. Close to downtown and Mayo Clinic."

Kahler Grand Hotel

10/10 Excellent

"Staff at the Kahler Grand were wonderful! The ease of access to all Mayo buildings from the hotel cannot be overstated. Definitely recommend!👍"

Holiday Inn Express Rochester South - Mayo Area by IHG

10/10 Excellent

"It was a very pleasant stay for us"

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"All good"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Very nice suite room, very quiet and restful. Front desk staff were helpful and great in helping us with dinner recommendations"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

8/10 Good

"Soap dispensers cumbersome to use hard to read labels. Stayed on fourth floor had elephants checking out at 4:15 am above me-no way normal people could make that much noise for 45 mins Happened next morning with new check in less obtrusive Will definitely request 5th with no one above. Have stayed several times so this was only this stay. Staff is stellar; Linda and Michelle most helpful"

The Berkman

10/10 Excellent

"Room was awesome! We had the 3 bedroom unit, which had a large and spacious balcony. Plenty of sunlight came through those windows. We couldn’t had had a better room!"

Frequently asked questions

Can I book a refundable hotel in Wykoff?

If you're looking for the flexibility to change your plans to Wykoff, most accommodations offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Wykoff be like during my visit?

The warmest months in Wykoff are usually July and August with an average temp of 68°F. January and February are the chilliest months when the average temp is 22°F. The rainiest months are June and May.

Why should I book my Wykoff hotel through Hotels.com?

There are plenty of reasons to book your Wykoff travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Keep exploring

More ways to book

Book Hotels in Wykoff on Hotels.com