Hotels in O Brien

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Check prices for these dates

This weekend
Jul 3 - Jul 5
Next weekend
Jul 10 - Jul 12

Where to stay in O Brien?

BBQ/picnic area

Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (135 reviews)
Discover welcoming comfort at this cozy Mayo motel where attentive staff earn high praise from guests. Enjoy convenient free WiFi and parking, with daily housekeeping that ensures a refreshing stay near Veteran's Memorial Park.
The price is $88
$95 total
includes taxes & fees
Jun 30 - Jul 1
Cindys Motel
Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (677 reviews)
This relaxing Live Oak hotel offers easy access to Blue Sink Canoe Launch and nearby hiking trails. After outdoor adventures, unwind in the outdoor pool. Clean rooms, helpful staff, free breakfast, and complimentary parking enhance your stay.
The price is $65
$71 total
includes taxes & fees
Jul 20 - Jul 21
Quality Inn White Springs Suwanee
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,003 reviews)
Wake up to complimentary breakfast before exploring nearby Lake DeSoto Farmers Market. This quiet motel offers free WiFi and parking, while the helpful staff ensures a comfortable stay. Cool off in the outdoor pool after a day of sightseeing.
The price is $59
$67 total
includes taxes & fees
Jun 30 - Jul 1
Days Inn by Wyndham Lake City I-10
Premium bedding, desk, blackout drapes, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (627 reviews)
Escape to this quiet, restful motel with comfortable beds and helpful staff. Located conveniently near O'Leno State Park, enjoy free WiFi and parking during your Lake City stay. Daily housekeeping ensures clean rooms that travelers consistently praise.
The price is $65
$73 total
includes taxes & fees
Jun 30 - Jul 1
Palms Garden Inn
Lobby

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (312 reviews)
This comfortable motel provides a daily continental breakfast and convenient access to Suwannee County Historical Museum. After exploring nearby attractions, cool off in the outdoor pool, then enjoy free Wi-Fi in your room.
The price is $77
$85 total
includes taxes & fees
Jun 30 - Jul 1
Econo Lodge Live Oak
Down comforters, pillowtop beds, blackout drapes, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (733 reviews)
Dive into the refreshing outdoor pool at this Lake City motel. Enjoy free WiFi, complimentary parking, and cooked-to-order breakfast daily from 6-9 AM. Near North Florida Speedway and Southside Sports Complex, with staff that guests consistently praise for their helpfulness.
The price is $65
$74 total
includes taxes & fees
Jul 20 - Jul 21
Super 8 by Wyndham Lake City
3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.8 out of 10, Excellent, (32 reviews)
Relax at this serene Mayo retreat along the Suwannee River, offering 3 outdoor pools and convenient dining at The Cookin' Shack. Explore nearby Peacock Springs State Park while enjoying free WiFi and parking throughout your stay.
The price is $27
$43 total
includes taxes & fees
Jun 30 - Jul 1
Suwannee River Rendezvous
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (269 reviews)
Unwind at this Lake City gem with an outdoor pool and on-site café. Grab a drink at the bar after exploring Regal UA Cinema 90 and Lake City Mall. Business travelers will appreciate free WiFi and parking.
The price is $116
$131 total
includes taxes & fees
Jul 5 - Jul 6
Courtyard By Marriott Lake City
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,061 reviews)
Located minutes from Lake City Mall and Regal UA Cinema 90, this welcoming hotel offers an indoor pool and fitness center. Enjoy free WiFi, parking, and breakfast before exploring the area. Business travelers appreciate the friendly staff.
The price is $87
$98 total
includes taxes & fees
Jun 30 - Jul 1
Best Western Plus Lake City
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very Good, (605 reviews)
This welcoming hotel offers free WiFi and parking in a convenient walkable location. Clean rooms provide a cozy retreat after exploring nearby Regal UA Cinema 90 and Lake City Mall. Helpful staff at the 24-hour front desk ensure a pleasant stay.
The price is $62
$70 total
includes taxes & fees
Jun 30 - Jul 1
Regal Inn
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (194 reviews)
Sink into premium bedding after exploring Lake City Columbia County Historical Museum. This hotel offers free WiFi and in-room coffeemakers, with Lake DeSoto Farmers Market just minutes away. Perfect for comfortable, convenient stays.
The price is $149
$167 total
includes taxes & fees
Jun 30 - Jul 1
The Blanche
Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,006 reviews)
Escape to this welcoming Lake City hotel where an outdoor pool provides refreshing relaxation. Located near Regal UA Cinema 90 and Lake City Mall, guests rave about the free breakfast and helpful staff.
The price is $103
$116 total
includes taxes & fees
Jul 5 - Jul 6
Comfort Suites Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,133 reviews)
This business-friendly Lake City hotel offers 24-hour fitness options alongside free breakfast, WiFi, and parking. Near Regal UA Cinema 90 and Lake City Mall, the indoor pool invites year-round swimming after exploring local attractions.
The price is $95
$107 total
includes taxes & fees
Jun 30 - Jul 1
La Quinta Inn & Suite by Wyndham Lake City
Lobby

Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.2 out of 10, Good, (573 reviews)
Escape to this tranquil Live Oak hotel where quiet surroundings create a restful atmosphere. Enjoy the outdoor pool after exploring nearby Suwannee County Historical Museum. Complimentary breakfast, WiFi, and parking enhance your stay while helpful staff ensure comfort.
The price is $77
$85 total
includes taxes & fees
Jul 7 - Jul 8
Quality Inn & Suites Live Oak I-10 Exit 283
Pillowtop beds, in-room safe, desk, blackout drapes

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,003 reviews)
This Lake City hotel offers free continental breakfast, WiFi and parking, with nearby access to Regal UA Cinema 90 and Lake City Mall. Travelers praise the helpful staff and clean rooms during their comfortable, business-friendly stay.
The price is $63
$71 total
includes taxes & fees
Jun 30 - Jul 1
Days Inn by Wyndham Lake City I-75
View from property

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (227 reviews)
Immerse yourself in natural beauty at these waterside cabins near Ruth B. Kirby Gilchrist Blue Springs State Park. Each cabin features a handy kitchenette and private patio, with free parking and climate control for a comfortable outdoor retreat.
The price is $161
$265 total
includes taxes & fees
Jul 29 - Jul 30
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Garden view

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (19 reviews)
Experience countryside charm at this Lake City hotel featuring furnished balconies or patios. Conveniently located near O'Leno State Park and Hog Lake, this serene farm retreat offers free WiFi and self parking for a relaxing getaway.
The price is $125
$213 total
includes taxes & fees
Jul 1 - Jul 2
Vista Verde Farm Retreat
Double Room, Non Smoking | Laptop workspace, free WiFi

High Springs Country Inn

High Springs Country Inn
2.0 star property
High Springs
8.4 out of 10, Very Good, (37 reviews)
This budget-friendly country inn provides free parking and round-the-clock front desk service in High Springs. Explore nearby attractions like the High Springs Museum while enjoying the convenient amenities of this cozy motel.
The price is $71
$80 total
includes taxes & fees
Jul 1 - Jul 2
High Springs Country Inn
Lobby sitting area

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (200 reviews)
Vibrant Lake City motel with 24-hour front desk and free WiFi, perfect for travelers exploring north Florida. Located near Regal UA Cinema 90 and Lake City Mall, with convenient access to medical facilities and free parking.
The price is $73
$82 total
includes taxes & fees
Jul 1 - Jul 2
Motel 6 – Lake City, Fl – Medical Center
Free WiFi, bed sheets

Gateway Inn

Gateway Inn
2.5 star property
Lake City
7.8 out of 10, Good, (191 reviews)
Unwind at this budget-friendly motel with daily housekeeping, close to Lake City Mall and area attractions. Free Wi-Fi keeps you connected while complimentary parking adds convenience for your North Florida adventure.
The price is $58
$66 total
includes taxes & fees
Jun 30 - Jul 1
Gateway Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Check out reviews of O Brien hotels guests love

Quality Inn Lake City

Quality Inn Lake City

10/10 Excellent
"Have stayed at this property before and I’ve never been disappointed. The front desk staff is friendly and welcoming. Rooms are always clean. Breakfast is just enough to get your day started."
Mark 1-night trip
Posted 11 hours ago
Quality Inn Lake City

Frequently asked questions

Can I book refundable hotels in O Brien?
If you want the flexibility to change your travel plans to O Brien, most accommodations provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in O Brien if I want a vacation home instead of a traditional hotel?
You'll find 5 vacation homes on our site.
What will the weather in O Brien be like during my vacation?
July and August are typically the warmest months in O Brien when the average temp is 80°F. January and February are the coldest months when the average temperature is 58°F. June and August are the months with the most rain.
Why should I book my O Brien hotel with Hotels.com?
There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.