Top 10 Hotels in O Brien, FL in 2026 (from $61)

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Where to stay in O Brien?

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

1. Comfort Suites Lake City

Lake City

$93

$105 total

includes taxes & fees

Oct 18 - Oct 19

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

2. La Quinta Inn & Suite by Wyndham Lake City

Lake City

$95

$106 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.

3. Courtyard By Marriott Lake City

Lake City

$107

$120 total

includes taxes & fees

Oct 11 - Oct 12

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

4. Fairfield Inn & Suites Lake City

Lake City

$104

$116 total

includes taxes & fees

Oct 11 - Oct 12

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

5. Best Western Plus Lake City

Lake City

$80

$90 total

includes taxes & fees

Nov 1 - Nov 2

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

6. Americas Best Value Inn Lake City

Lake City

$67

$76 total

includes taxes & fees

Oct 4 - Oct 5

A covered outdoor area with a paved walkway, benches, and potted plants.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

7. Cindys Motel

Mayo

$89

$96 total

includes taxes & fees

Oct 4 - Oct 5

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.

A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.

An EV charging station with two signs indicating it is for guest use only while charging.

8. Hampton Inn & Suites Lake City

Lake City

$105

$118 total

includes taxes & fees

Oct 18 - Oct 19

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

9. Tru by Hilton Lake City

Lake City

$100

$113 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

10. Super 8 by Wyndham Lake City

Lake City

$61

$69 total

includes taxes & fees

Nov 2 - Nov 3

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.

A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

11. TownePlace Suites by Marriott Lake City

Lake City

$119

$134 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.

A white building with multiple windows and a sign that reads 'Quality Inn.'

A reception area with a counter, a coffee machine, and a potted plant.

12. Quality Inn Lake City

Lake City

$80

$90 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with two beds, a blue wall, and a window with curtains.

A modern kitchen with a built-in stove, a coffee machine, and a sink. There is a trash can and a potted plant near the sink.

A bathroom with a beige sink, a large mirror, and a white trash bin.

13. Gateway Inn

Lake City

$47

$53 total

includes taxes & fees

Oct 4 - Oct 5

A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a bathroom visible in the background.

A pool area with a fenced deck, palm trees, and a small building with a red roof.

A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.

14. Baymont by Wyndham Lake City I-75

Lake City

$58

$65 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.

15. Home2 Suites by Hilton Lake City

Lake City

$114

$128 total

includes taxes & fees

Oct 18 - Oct 19

A room with a window, a sofa, a table, and a wall-mounted heater.

A kitchen with a coffee station, including a coffee maker, cups, and condiments.

A hotel room with two beds, a desk, a chair, a window with a view, and a wall-mounted lamp.

A building with a flat roof, large windows, and a parking lot in front.

16. Motel 6 – Lake City, Fl – Medical Center

Lake City

$68

$77 total

includes taxes & fees

Oct 4 - Oct 5

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel with a swimming pool, white lounge chairs, and a fenced area.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

A hotel room with a bed, desk, chair, and sofa.

17. Quality Inn White Springs Suwanee

White Springs

$66

$72 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A kitchen with a black refrigerator and a microwave on a wooden shelf.

A reception area with a wooden counter, a clock, and a computer on a desk.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

18. Days Inn by Wyndham Lake City I-75

Lake City

$72

$81 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.

A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.

A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

19. Holiday Inn & Suites Lake City by IHG

Lake City

$99

$111 total

includes taxes & fees

Nov 1 - Nov 2

A hotel reception area with a reception desk, seating area, and a view of the parking lot.

A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.

A hotel room with two beds, a bedside table with a lamp, a phone, and a window with curtains.

A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

20. Econo Lodge Live Oak

Live Oak

$73

$80 total

includes taxes & fees

Oct 6 - Oct 7

View all properties

Go beyond your typical stay in O Brien

Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

See all hotels in O Brien

Check out reviews of O Brien hotels guests love

TownePlace Suites by Marriott Lake City

Lake City

10/10 Exceptional

Penny

Americas Best Value Inn Lake City

Lake City

10/10 Exceptional

Nathaly

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A wooden cabin with a porch, a front door, and a small window.

A serene lakeside campsite with picnic tables and chairs.

Suwannee River Rendezvous

Mayo

10/10 Exceptional

Beth

Holiday Inn & Suites Lake City by IHG

Lake City

10/10 Exceptional

Often hotels think that just because you're bringing a dog you deserve the most run down room in the building, or a pet fee that's out of this world, but not here. After a road trip filled with questionable hotel rooms at high prices, we finally spent a night in actually clean sheets. We didn't feel the need to check for bedbugs or see if there were crumbs on the floor that our dogs could eat. We'd definitely stay again. Just wish more holiday inns were this pet friendly.

Franziska

Days Inn by Wyndham Lake City I-75

Lake City

10/10 Exceptional

Anonymous traveler

A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.

A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.

A row of motel buildings with a fire hydrant and trees in front.

High Springs Country Inn

High Springs

10/10 Exceptional

Patrick

Hampton Inn & Suites Lake City

Lake City

10/10 Exceptional

Strother

La Quinta Inn & Suite by Wyndham Lake City

Lake City

10/10 Exceptional

Christopher

Fairfield Inn & Suites Lake City

Lake City

10/10 Exceptional

Steven

Best Western Plus Lake City

Lake City

10/10 Exceptional

waqar

Cindys Motel

Mayo

10/10 Exceptional

The place is lovely. The people here are so welcoming and friendly. I left my phone on the nightstand after check out and the gentleman who was working Saturday walked over to the diner where we were having breakfast and handed it to me. The room is good sized, bed and pillows are comfortable. I love the old Florida motels, and this will definitely be a place we will definitely come back to.

Michelle

Tru by Hilton Lake City

Lake City

10/10 Exceptional

Richard

Home2 Suites by Hilton Lake City

Lake City

10/10 Exceptional

Kimberly

Quality Inn Lake City

Lake City

10/10 Exceptional

Anonymous traveler

A spacious living area with a large chandelier, a sofa set, a coffee table, and a patterned floor.

A storefront with a glass door and a brick wall. The sign above the door reads "The Blanche."

A hotel with a classic facade, featuring a prominent sign reading "HOTEL BLANCHE".

A spacious lobby with a large chandelier, two sofas, a glass coffee table, and a patterned carpet.

The Blanche

Lake City

10/10 Exceptional

John

Gateway Inn

Lake City

10/10 Exceptional

Hugo

Frequently Asked Questions

Can I book refundable hotels in O Brien?

If you want the flexibility to change your travel plans to O Brien, most accommodations provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in O Brien if I want a vacation home instead of a traditional hotel?

You'll find 5 vacation homes on our site.

What will the weather in O Brien be like during my vacation?

July and August are typically the warmest months in O Brien when the average temp is 80°F. January and February are the coldest months when the average temperature is 58°F. June and August are the months with the most rain.

Why should I book my O Brien hotel with Hotels.com?

There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.